The Effects of Tension on Acetylstrophanthidin-Induced Transient Depolarizations and Aftercontractions in Canine Myocardial and Purkinje Tissues
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Effect of repeatedly injected foreign protein in rabbits fed a lipid-rich, cholesterol-poor diet. Am J Path 73: 265-292, 1973 18. Moore S: Thromboatherosclerosis in normolipemic rabbits; a result of continued endothelial damage. Lab Invest 29: 478-484, 1973 19. Stemerman MB, Ross R: Experimental arteriosclerosis. I. Fibrous plaque formation in primates; an electron microscopic study. J Exp Med 136: 769-789, 1972 20. Stemerman MB, Pitlick F, Cintron J: Tissue factor and the injured artery; detection of "endothelial cells" by distinct antigenicity during re-endothelialization (abstr). Fed Proc 33: 2363, 1974
منابع مشابه
The effects of tension on acetylstrophanthidin-induced transient depolarizations and aftercontractions in canine myocardial and Purkinje tissues.
Transmembrane potentials and contractile activity were recorded from isolated canine Purkinje and ventricular muscle preparations exposed to acetylstrophantidin (AS) and subjected to a resting tension equal to 80% of that required to elicit peak developed tension. AS induced transient depolarizations (TD's) accompanied by aftercontractions in Purkinje tissue. AS also induced aftercontractions i...
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Transient depolarizations (TDs) appeared in canine Purkinje tissue but not in cardiac muscle during exposure to 1-2 X 10~ g/ml of acetylstrophanthidin. At low levels of toxicity, the TDs were associated with a decrease in threshold and an increase in automaticity. As intoxication progressed, the TDs coincided with transient periods of increased threshold and conduction block. Propagation from m...
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The role of calcium ions (Ca) in the generation of transient depolarizations (TDs) by acetylstrophanthidin was examined. Transmembrane activity was recorded from isolated canine false tendons exposed to acetylstrophanthidin; concentrations from 7.5 X 10"" to 2 X 10-" g/ml caused TDs coupled to driven action potentials and depressed slow diastolic depolarization. TDs could reach threshold and in...
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The [Ca2+]-activated photoprotein aequorin was used to measure [Ca2+] in canine cardiac Purkinje fibers during the positive inotropic and toxic effects of ouabain, strophanthidin, and acetylstrophanthidin. The positive inotropic effect of these substances was associated with increases in the two components of the aequorin signal, L1 and L2. On the average, strophanthidin at 10(-7) M produced st...
متن کاملEffect of Calcium on Acetylstrophanthidin-lnduced Transient Depolarizations in Canine Purkinje Tissue
The role of calcium ions (Ca) in the generation of transient depolarizations (TDs) by acetylstrophanthidin was examined. Transmembrane activity was recorded from isolated canine false tendons exposed to acetylstrophanthidin; concentrations from 7.5 X 10"" to 2 X 10-" g/ml caused TDs coupled to driven action potentials and depressed slow diastolic depolarization. TDs could reach threshold and in...
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تاریخ انتشار 2005